Quantitative Phase Imaging cameras

What is Quantitative Phase Imaging (QPI)?

Quantitative Phase Imaging (QPI) is a powerful and versatile imaging technique the field of biological imaging. It offers a unique approach by measuring the phase shift of light as it passes through a transparent or semi-transparent sample, such as biological cells or tissues. Unlike traditional imaging techniques that rely on the absorption or reflection of light, Quantitative Phase Imaging applied to life science applications enables direct measurement of the refractive index distribution in biological sample. This capability provides quantitative information about the structure and properties of the sample, including its thickness, shape, and density.

Moreover, Quantitative Phase Imaging has applications beyond biological imaging. It has found utility in materials science and nanotechnology where precise measurements of refractive index variations in materials are crucial for studying thin film and nanostructures properties. Quantitative Phase Imaging techniques have been developed to enhance imaging capabilities and provide valuable quantitative data for a wide range of scientific and industrial applications.

Phasics SID4 sc8 quantitative phase imaging camera showing the measurement of a biological sample

Why use Quantitative Phase Imaging?

Quantitative Phase Imaging (QPI) has revolutionized the realm of biological imaging, providing researchers and scientists with a profound insight into microscopic biological samples. By capturing and analyzing the phase information, QPI enables the visualization and characterization of transparent objects with remarkable precision and resolution, eliminating the need for staining or labeling. Its non-invasive nature makes it particularly valuable for studying live cells and dynamic processes, facilitating real-time monitoring without disrupting the natural environment.

Quantitative Phase Imaging (QPI) extends its applications in other domains such as materials science and nanoscience. In materials science, QPI is a powerful approach for investigating the structural properties and behaviors of materials at the microscopic scale. By quantitatively measuring refractive index variations, QPI provides comprehensive insights into material structures. This knowledge enables the development of advanced materials and optimization of their performance. Additionally, in the field of nanoscience, QPI offers a non-invasive means of visualizing and characterizing nanoscale structures and phenomena. By capturing high-resolution phase information, QPI provides a quantitative assessment of refractive index changes in nanomaterials. This capability supports researchers to unravel the unique properties and behaviors exhibited by nanoparticles, nanodevices, and other nanoscale structures.

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